Process for producing antibiotic salinomycin

Details Process for producing antibiotic salinomycin Process for producing antibiotic salinomycin

C - Chemistry, Metallurgy

12

P

195/101

C12P 1/00 (2006.01) C12N 1/20 (2006.01) C12P 17/06 (2006.01) C12P 19/54 (2006.01)

Patent

CA 1292713

ABSTRACT There is disclosed a biosynthesis process for producing antibiotic salinomycin by means of producing strains of the microorganism Streptomyces albus, which are derived from the strain ATCC 21838. The microorganism is cultivated under submersed aerobic conditions in a nutrient medium, containing an organic carbon source, a nitrogen source, mineral salts, the amino acid methionine and small quantities of vitamins, either D-biotin or pyridoxin (B6). By the presence of vitamins and methionine, a greater and more stable yield of the antibiotic is achieved more quickly, which makes the process shorter. As anti-foaming agents there are used vegetable oils and silicone type anti-foaming agents. From the fermented broth the antibiotic is isolated in a standard manner.

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