Process for producing atorvastatin, pharmaceutically...

Details Process for producing atorvastatin, pharmaceutically... Process for producing atorvastatin, pharmaceutically...

C - Chemistry, Metallurgy

12

P

C12P 17/10 (2006.01)

Patent

CA 2612293

A novel process for producing atrovastatin, pharmaceutically acceptable salts thereof, and intermediates thereof using an aldolase is described. Compounds so prepared are useful as inhibitors of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agents.

La présente invention décrit un nouveau procédé de fabrication de l~atorvastatine, de ses sels pharmaceutiquement acceptables et de ses intermédiaires en utilisant une aldolase. Des composés ainsi préparés sont utiles comme inhibiteurs de l~HMG-CoA réductase et peuvent ainsi être utilisés comme agents hypolipémiant et hypocholestérolémique.

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