C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07C 327/30 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 9/14 (2006.01) C12N 15/52 (2006.01) C12N 15/53 (2006.01) C12P 17/08 (2006.01)
Patent
CA 2402398
22,23-Dihydroavermectin B1a, which is useful in drugs, veterinary drugs and pesticides, can be produced by direct fermentation. Thus, the troublesome and difficult industrial steps of purifying avermectin B1a and chemically modifying avermectin B1a involved in the conventional are can be omitted and therefore 22,23-dihydroavermectin B1a can be industrially produced while largely saving the cost and time. Moreover, a preparation containing 22,23- dihydroavermectin B1a alone, which is highly efficacious as a drug, can be produced.
Selon l'invention, la 22,23-dihydroavermectine B1a, utilisée dans des médicaments, des médicaments vétérinaires et des pesticides, peut être produite par fermentation directe. Ainsi, les étapes problématiques et difficiles de purification de l'avermectine B1a et de modification chimique de l'avermectine B1a intervenant dans la technique antérieure peuvent être supprimées, la 22,23-dihydroavermectine B1a pouvant alors être produite industriellement avec rapidité et à peu de frais. En outre, il est possible de produire une préparation contenant de la 22,23-dihydroavermectine B1a isolée, substance hautement efficace comme médicament.
Endo Hirofumi
Hashimoto Shinichi
Ikeda Haruo
Kanda Yutaka
Omura Satoshi
Fetherstonhaugh & Co.
Kyowa Hakko Kogyo Co. Ltd.
The Kitasato Institute
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