Process for producing benzo[c]phenanthridine derivative

Details Process for producing benzo[c]phenanthridine derivative Process for producing benzo[c]phenanthridine derivative

C - Chemistry, Metallurgy

07

D

C07D 491/056 (2006.01) C07D 221/18 (2006.01)

Patent

CA 2584617

A compound represented by the following formula (1): [wherein R1 and R2 each independently represents hydroxy, provided that R1 and R2 may be bonded to each other to form methylenedioxy, etc.; X represents halogeno; and R3 represents a protective group] is subjected to a cyclization reaction with the aid of an organic silyl hydride and then aromatized with an oxidizing agent to produce a benzo[c]phenanthridine derivative represented by the following formula (2): [wherein R1, R2, and R3 have the same meanings as defined above].

On soumet un composé représenté par la formule (1) suivante : [Formule chimique 1] (1) [dans laquelle R1 et R2 représentent chacun indépendamment un hydroxy, à condition que R1 et R2 puissent être liés l'un à l'autre pour former un méthylènedioxy, etc. ; X représente un halogéno ; et R3 représente un groupe protecteur] à une réaction de cyclisation à l'aide d'un hydrure de silyle organique et on l'aromatise ensuite avec un agent oxydant pour produire un dérivé de benzo[c]phénanthridine représenté par la formule (2) suivante : [Formule chimique 2] (2) [dans laquelle R1, R2 et R3 ont les mêmes significations que celles définies ci-dessus].

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