Process for producing beta-lactamase inhibitor

C - Chemistry – Metallurgy – 07 – D

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C07D 499/86 (2006.01) C07D 499/00 (2006.01)

Patent

CA 2016500

A process for producing the compound [2S-(2.alpha.,3.beta.,5.alpha.)]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl- methyl)-4-thia-1-azabicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropionate with a solution of bis(trimethylsilyl)acetamide and 4-methoxyphenol in toluene at 80-100°C for 18-30 hours followed by filtering the resulting solution and cooling the filtrate to 0-10°C.

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