Process for producing cephalosporins

Details Process for producing cephalosporins Process for producing cephalosporins

C - Chemistry, Metallurgy

07

D

260/108

C07D 501/04 (2006.01) C07D 499/00 (2006.01) C07D 501/18 (2006.01)

Patent

CA 1039709

ABSTRACT OF THE DISCLOSURE A process for producing a compound of the formula (I) Image (I) wherein R2 is a hydrogen atom or an ester protective group, which is useful as a precursor for the production of cephalosporin derivatives, comprising reacting a phosphoramide derivative of cephalosporin of the formula (II) Image (II) wherein R1 is a lower alkyl group and R2 is as defined above, with a phosphorus acid. A further embodiment includes preparing the phosphoramide derivative of cephalosporin of the formula (II) by reacting a compound of the formula (III) Image (III) wherein R1 and R2 are as defined above, with an acid compound.

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