C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/129, 195/1.3
C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12N 15/52 (2006.01) C12P 7/04 (2006.01) C12P 17/02 (2006.01)
Patent
CA 1297439
Title: A process for producing compounds containing a terminal hydroxyl or epoxy group; and microorganisms suitable therefor. Abstract of the disclosure: This invention relates to a process for the microbiological production of compounds containing a terminal hydroxyl or epoxy group from an aliphatic substrate or a substrate with an aliphatic side chain, using micro- organisms genetically engineered so that they have retained their capacity to perform the terminal oxidation of the substrate, but are no longer able to convert the resulting oxidation product further to any significant extent. Preferred substrates are n-alkanes, n-alkenes, and n-alkadienes containing 6-12 carbon atoms. Preferred micro-organisms are genetically engineered Pseudomonas oleovorans and Pseudomonas putida strains lacking an active plasmidic alkanol-dehydrogenase gene. The invention also relates to micro-organisms thus genetically engineered.
556478
Lageveen Roland Gerhard
Witholt Bernard
Fetherstonhaugh & Co.
Rijksuniversiteit Te Groningen
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