Process for producing cyclobutane derivative

Details Process for producing cyclobutane derivative Process for producing cyclobutane derivative

C - Chemistry, Metallurgy

07

C

260/477, 260/479

C07C 275/26 (2006.01) C07C 215/42 (2006.01) C07C 215/44 (2006.01) C07C 217/52 (2006.01) C07C 229/48 (2006.01) C07C 271/24 (2006.01) C07D 205/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2027845

ABSTRACT OF THE DISCLOSURE The present invention relates to a process for producing cyclobutane derivatives represented by general formula (28): Image (28) (wherein R represents a substituent; R2 represents an electron attracting group and Nu represents a substituent corresponding to nucleophilic reagent), by reacting a compound represented by general formula (27): Image (27) (wherein R has the same significance as defined above and R1 represents an electron attracting group) with nucleophilic reagents Nu? in a solvent. The compounds of formula (28) are useful as intermediates for synthesis of, for example, 9-[2,3-bis(hydroxymethyl)cyclobutan-1-yl]guanine which is expected to be useful as an antiviral agent.

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