Process for producing d,1-5-methyltetrahy-drofolic acid and...

Details Process for producing d,1-5-methyltetrahy-drofolic acid and... Process for producing d,1-5-methyltetrahy-drofolic acid and...

C - Chemistry, Metallurgy

07

D

260/242.13

C07D 475/04 (2006.01) A61K 47/18 (2006.01)

Patent

CA 1093554

ABSTRACT A process for producing d,1-5-methyltetrahydrofolic acid and its salts of the formula (I) Image where X is hydrogen, an alkaline metal or the equivalent of an alkaline earth metal, by reduction of folic acid with NaBH4 and methylation of tetrahydrofolic acid so obtained with aque- ous solutions of formaldehyde and sodium borohydride in an inert gas atmosphere.

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