Process for producing d-penicillamine

Details Process for producing d-penicillamine Process for producing d-penicillamine

C - Chemistry, Metallurgy

07

D

260/526, 260/310

C07D 277/06 (2006.01) C07C 103/52 (1980.01)

Patent

CA 1042901

ABSTRACT OF THE DISCLOSURE The present invention relates to a process for producing D-penicillamine from D,L penicillamine. In particular the present invention provides a process for producing D-penicillamine from D,L-penicillamine which comprises reacting a protected derivative of D,L-penicillamine of the formula Image where Ac is benzoyl, tosyl, nitrophenyl-sulfenyl, formyl, acetyl or propionyl, and R1 and R2 are hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, phenyl or tolyl or R1 and R2 together with the adjacent carbon atoms of the thiazoline ring form a cycloalkylene ring of 5 to 8 carbon atoms with an optically active base selected from L-lysine or a salt thereof separating the salt so formed from the reaction mixture, converting said salt to the derivative of D-penicillamine and converting the derivative of D-penicillamine to D-penicillamine.

190169

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