Process for producing defatted heparin tissue for heparin...

Details Process for producing defatted heparin tissue for heparin... Process for producing defatted heparin tissue for heparin...

C - Chemistry, Metallurgy

12

P

167/199, 195/66

C12P 1/00 (2006.01) C08B 37/10 (2006.01)

Patent

CA 1078767

ABSTRACT OF THE DISCLOSURE An improved process for producing defatted heparin tissue is disclosed wherein frozen heparin-bearing tissue is particulated, thawed and warmed in a heat exchanger, fermented at temperatures ranging from 45°-95°F. for 2 to 15 hours and subjected to azeotropic distillation and extraction to substantially remove water and fat. Putre- faction and odor are avoided, the tissue has improved uniformity in biochemical content, is lower in fat content and is capable of high heparin yields when processed according to known procedures. The defatted tissue is exceptionally permeable to heparin recovery solutions and heparin isolation is facilitated.

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