Process for producing di(pyrimidine nucleoside...

Details Process for producing di(pyrimidine nucleoside... Process for producing di(pyrimidine nucleoside...

C - Chemistry, Metallurgy

07

H

C07H 19/10 (2006.01)

Patent

CA 2659595

Pyrimidine nucleoside 5'-triphosphoric acid is converted into pyrimidine nucleoside 5'-(cyclic triphosphoric acid) with a condensation agent. Subsequently, the pyrimidine nucleoside 5'-(cyclic triphosphoric acid) obtained is reacted with pyrimidine nucleotide in the presence of a salt of a metal selected among magnesium, manganese, and iron to synthesize di(pyrimidine nucleoside 5'-)polyphosphate. A non-protected pyrimidine nucleoside 5'-phosphoric acid compound can be used as a raw material in this process and the target di(pyrimidine nucleoside 5'-)polyphosphate can be synthesized in a yield of 50% or higher. The process is hence suitable for the mass synthesis of di(pyrimidine nucleoside 5'-)polyphosphate.

Selon l'invention, le (nucléoside pyrimidique)-5'-(acide triphosphorique) est converti en (nucléoside pyrimidique)-5'-(acide triphosphorique cyclique) avec un agent de condensation. A la suite de cela, on fait réagir le (nucléoside pyrimidique)-5'-(acide triphosphorique cyclique) obtenu avec un nucléotide pyrimidique en présence d'un sel d'un métal sélectionné parmi le magnésium, le manganèse et le fer pour synthétiser le di(nucléoside pyrimidique-5'-)polyphosphate. On peut utiliser un composé (nucléoside pyrimidique)-5'-(acide phosphorique) non protégé en tant que matière première dans ce procédé et on peut synthétiser le di(nucléoside pyrimidique-5'-)polyphosphate cible avec un rendement de production supérieur ou égal à 50 %. Le procédé convient donc pour la synthèse en masse de di(nucléoside pyrimidique-5'-)polyphosphate.

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