C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/04 (2006.01) C07D 317/18 (2006.01) C07D 317/32 (2006.01) C07D 473/00 (2006.01) C07D 473/16 (2006.01)
Patent
CA 2473736
The present invention relates to a process conducted in a single reaction vessel for producing a dioxolane nucleoside analogue of formula I or a pharmaceutically acceptable salt thereof; the process comprising the steps of adding a Lewis acid, a silylating agent and a non-silylated purine or pyrimidine base or an analogue thereof to a dioxolane of formula II. The invention also provides a process for producing a dioxolane compound of formula III; by reacting a dioxolane compound of formula IV in a suitable solvent in the presence of DIB and I2, using a suitable source of energy.
L'invention concerne un procédé mis en oeuvre dans une cuve de réaction simple pour produire un analogue de nucléoside de dioxolane de formule (I) ou un de ses sels pharmaceutiquement acceptables. Ledit procédé comprend comme étapes : ajouter un acide de Lewis, un agent de silylation et une base purique pyrimidique non silylé ou un de leurs analogues à un dioxolane de formule (II). L'invention concerne en outre un procédé permettant de produire un composé dioxolane de formule (III), par réaction d'un composé dioxolane de formule (IV) dans un solvant approprié en présence de DIB et I¿2?, à l'aide d'une source d'énergie appropriée.
Bydlinski Gregory
Cimpoia Alex
Yu Qing
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Shire Biochem Inc.
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