Process for producing drospirenone (6.beta.,7.beta.;...

Details Process for producing drospirenone (6.beta.,7.beta.;... Process for producing drospirenone (6.beta.,7.beta.;...

C - Chemistry, Metallurgy

07

J

C07J 53/00 (2006.01)

Patent

CA 2261137

Process for the production of drospirenone (6B,7B; 15B,16B- dimethylene-3-oxo-17.alpha.-pregn-4-ene-21,17-carbolactone, DRSP) (1) and 7.alpha.-(3-hydroxy-1-propyl)-6.beta.,7.beta.; 15.beta.,16.beta.- dimethylene-5.beta.- androstane-3.beta.,5,17.beta.-triol (ZK 92836) and 6.beta.,7.beta.; 15.beta.,16.beta.- dimethylene-5.beta.-hydroxy-3-oxo-17.alpha.-androstane-21,17-carbolactone (ZK 90965) as intermediate products of the process.

L'invention concerne un procédé de préparation de drospirénone (6 beta ,7 beta ;15 beta ,16 beta -diméthylène-3-oxo-17 alpha -pregn-4-ène-21,17-carbolactone, <u>DRSP</u>) (I) et 7 alpha -(3-hydroxy-1-propyle)-6 beta ,7 beta ;15 beta ,16 beta -diméthylène-5 beta -androstane-3 beta ,5,17 beta -triol (<u>ZK 92836</u>) et 6 beta ,7 beta ;15 beta ,16 beta -diméthylène-5 beta -hydroxy-3-oxo-17 alpha -androstane-21,17-carbolactone (<u>ZK 90965</u>) utilisés comme produits intermédiaires du procédé.

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