Process for producing erythro-3-amino-2-hydroxybutyric acid...

Details Process for producing erythro-3-amino-2-hydroxybutyric acid... Process for producing erythro-3-amino-2-hydroxybutyric acid...

C - Chemistry, Metallurgy

07

C

C07C 229/34 (2006.01) C07C 227/18 (2006.01) C07C 227/26 (2006.01) C07C 227/32 (2006.01) C07C 253/08 (2006.01) C07C 253/30 (2006.01) C07C 255/38 (2006.01) C07C 269/06 (2006.01) C07C 271/22 (2006.01) C07C 303/40 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01) C07C 319/20 (2006.01) C07C 323/58 (2006.01) C07D 209/48 (2006.01) C07D 209/66 (2006.01) C07C 229/22 (2006.01) C07C 255/43 (2006.01)

Patent

CA 2312385

The present invention relates to a process for reacting .alpha.~aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or the like to synthesize 3-amino-2-hydroxybutyronitrile derivatives in high yields and high erythro selectivity. When optically active .alpha.~aminoaldehyde derivatives are used, racemization hardly occurs during the reaction, and the desired products are obtained in high optical purity.

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