B - Operations – Transporting – 01 – D
Patent
B - Operations, Transporting
01
D
B01D 9/00 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2376269
The method of producing fine medicament particles suitable for inhalation, particles produced by the method and apparatus suitable for carrying out the method is claimed. The method comprises contacting a stream or streams of a solution of medicament with a stream or streams of a liquid in which the medicament is insoluble in a confined chamber such that a region of intense turbulence and mixing is formed. The medicament crystallises as fine particles with minimal inclusion of solvent or anti-solvent impurities. The crystallised medicament is separated from suspension by standard techniques. Careful control of relative stream velocity, solution concentration and proportion of solution and anti-solvent in the streams ensures a uniform product.
L'invention concerne un procédé de production de fines particules médicinales pouvant être inhalées, des particules produites selon ce procédé et un dispositif permettant de le mettre en oeuvre. Ce procédé consiste à mettre en contact, dans une enceinte confinée, au moins un flux d'une solution de médicament avec au moins un flux d'un liquide dans lequel le médicament n'est pas soluble, de manière à former une région de forte turbulence et de mélange. Le médicament cristallise sous forme de fines particules, avec l'inclusion minimale d'impuretés de solvant ou d'anti-solvant. On sépare ensuite le médicament cristallisé de la suspension par des techniques classiques. Une régulation minutieuse de la vitesse relative des flux, de la concentration de la solution ainsi que de la proportion de solution et d'anti-solvant dans les flux assure un produit uniforme.
Begon Dominique
Guillaume Pfefer
Kohl Michael
Rhone-Poulenc Industrialisation
Ridout & Maybee Llp
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