Process for producing fused imidazole compound, and...

Details Process for producing fused imidazole compound, and... Process for producing fused imidazole compound, and...

C - Chemistry, Metallurgy

07

F

C07F 3/06 (2006.01)

Patent

CA 2700690

A process for industrially advantageously producing a steroid C17,20- lyase inhibitor represented by the following general formula (I); and a Reformatsky reagent in a stable form which is suitable for use in the production process. Either a specific .beta.-hydroxy ester compound derivative obtained from a specific carbonyl compound by the Reformatsky reaction or a salt of the compound is reduced in the presence of a metal/hydrogen complex compound and a metal halide and then subjected to ring closure to thereby obtain a compound represented by the general formula (I): (I) wherein the symbols have the same meanings as defined in the description. In the Reformatsky reaction, a stable solution of the compound represented by BrZnCH2COOC2H5 or crystals of the compound represented by (BrZnCH2COOC2H5.cndot.THF)2 are useful.

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