Process for producing .gamma.-hydroxyamino acid derivatives...

C - Chemistry – Metallurgy – 07 – C

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C07C 215/08 (2006.01) A23L 1/236 (2006.01) C07D 209/20 (2006.01)

Patent

CA 2423691

The present invention can easily convert dihydroisoxazole derivatives to .gamma.-hydroxyamino acid derivatives important as various synthetic intermediates by a catalytic hydrogenation reaction. Especially, high-purity monatins expected as sweeteners or ingredients thereof can be obtained by subjecting a 5-indolylmethyl-4,5-dihydroisoxazole-3,5-dicarboxylic acid to a catalytic hydrogenation reaction.

La présente invention permet de convertir aisément des dérivés de dihydroisoxazole en dérivés d'acide gamma-hydroxyamino constituant d'importants intermédiaires dans diverses synthèses, cela par hydrogénation catalytique. On peut en particulier obtenir des monatines de haute pureté destinées à être utilisées comme édulcorants ou comme ingrédients de ces derniers, cela en soumettant un acide 5-indolylméthyl-4,5-dihydroisoxazole-3,5-dicarboxylique à une hydrogénation catalytique.

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