Process for producing hmg-coa reductase inhibitor

Details Process for producing hmg-coa reductase inhibitor Process for producing hmg-coa reductase inhibitor

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C07H 21/00 (2006.01) C07K 14/32 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 9/04 (2006.01) C12N 15/63 (2006.01) C12P 7/62 (2006.01) C12P 17/06 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2360080

A protein having an activity of hydroxylating compounds originating in a microorganism belonging to the genus Bacillus and represented by general formula (I-a) or lactones formed by cyclizing these compounds; a DNA encoding this protein; a recombinant DNA containing this DNA; etc.; in formula (I-a) R1 represents hydrogen, optionally substituted alkyl or an alkali metal; and R2 represents optionally substituted alkyl or optionally substituted aryl.

L'invention concerne une protéine ayant une activité de composés d'hydroxylation provenant d'un micro-organisme appartenant au genre bacillus et de formule générale (I-a) ou provenant de lactones formée par cyclisation de ces composés, un ADN codant ces protéines, un ADN recombinant contenant cet ADN, etc. Dans la formule générale (I-a) R?1¿ est hydrogène, alkyle éventuellement substitué ou métal alcalin, et R?2¿ est alkyle éventuellement substitué ou est aryle éventuellement substitué.

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