Process for producing hmg-coa reductase inhibitors

Details Process for producing hmg-coa reductase inhibitors Process for producing hmg-coa reductase inhibitors

C - Chemistry, Metallurgy

12

P

C12P 7/62 (2006.01) C12P 17/06 (2006.01)

Patent

CA 2358927

A process for producing compounds (II-a) or compounds (II-b), which are respectively hydroxylated products of compounds represented by general formula (I-a) (here in after referred to as the compounds (I-a)) or closed lactone derivatives thereof (hereinafter referred to as the compounds (I-b)). In formula (I-a) R1 represents hydrogen, optionally substituted alkyl or an alkali metal; and R2 represents optionally substituted alkyl or optionally substituted aryl. This process is characterized by treating in an aqueous medium the compounds (I-a) or (I-b) with an enzyme source comprising a microorganism having an activity of hydroxylating the compounds (I-a) or (I- b), having no sporulability and showing no hyphal growth, or an optionally processed culture of the microorganism and collecting the compounds (II-a) or (II-b) from the aqueous medium.

L'invention concerne un procédé de production de composés (II-a) ou (II-b), qui sont respectivement des produits hydroxylés de composés de la formule générale (I-a) (ci-après dénommés composés (I-a)) ou des dérivés de lactone fermés issus de ces composés (ci-après dénommés composés (I-b)). Dans ladite formule, R?1¿ est hydrogène, alkyle éventuellement substitué ou un métal alcalin; et R?2¿ est alkyle éventuellement substitué ou aryle éventuellement substitué. Le procédé consiste à traiter les composés (I-a) ou (I-b) dans un milieu aqueux, au moyen d'une source enzymatique contenant un micro-organisme ayant une activité d'hydroxylation des composés (I-a) ou (I-b) ou ne possédant aucune propriété de sporulation ou de croissance fongique. Le procédé consiste autrement à traiter lesdits composés au moyen d'une culture du micro-organisme éventuellement épurée aux fins de recueillir les composés (II-a) ou (II-b) dudit milieu aqueux.

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