Process for producing isoprenoid compounds by microorganisms

Details Process for producing isoprenoid compounds by microorganisms Process for producing isoprenoid compounds by microorganisms

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 7/66 (2006.01) C12P 23/00 (2006.01) C12N 9/00 (2006.01) C12N 15/52 (2006.01)

Patent

CA 2630341

Disclosed is a process for producing an isoprenoid compound by culturing a prokaryote host cell transformed with a vector containing a DNA which encodes a protein having an activity to catalyze a reaction to produce 2-C--methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate, and recovering the isoprenoid compound from the culture. The isoprenoid compound may be useful as a pharmaceutically active ingredient.

La présente invention concerne un procédé permettant de produire un composé isoprénoïde par la mise en culture d'une cellule procaryote hôte transformée au moyen d'un vecteur renfermant de l'ADN codant une protéine capable de catalyser une réaction produisant du 2-C-méthyl-D-érythritol 4-phosphate à partir de 1-déoxy-D-xylulose 5-phosphate, ainsi qu'un procédé permettant de récupérer ledit composé isoprénoïde de la culture, lequel peut être utilisé comme principe actif dans des produits pharmaceutiques.

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