Process for producing isoxazole derivatives

Details Process for producing isoxazole derivatives Process for producing isoxazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 261/08 (2006.01)

Patent

CA 2050345

The present invention provides a process for producing isoxazole derivatives represented by the formula Image (II) wherein R1 and R2 are the same or different and are each a hydrogen atom or lower alkoxyl, and R3 is cyano or alkoxycarbonyl, the process being characterized by oxidizing an .alpha.,.beta.-unsaturated ketoxime derivative represented by the formula Image (I) wherein R1, R2 and R3 are as defined above. The isoxazole derivatives (II ) to be produced by the process of the present invention are useful as intermediates for preparing (3,4-diarylisoxazol-5-yl)acetic acid derivatives which are useful as anti-inflammatory agents, analgesics and antipyretics.

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