Process for producing ketoprofen and...

Details Process for producing ketoprofen and... Process for producing ketoprofen and...

C - Chemistry, Metallurgy

07

C

C07C 59/84 (2006.01) C07C 51/06 (2006.01) C07C 51/377 (2006.01) C07D 209/34 (2006.01)

Patent

CA 2288125

A process for producing ketoprofen by benzoylating 3-methyl-2-indolinone with a benzoyl halide, cleaving the amido bond forming the five-membered ring moiety of the formed 5-benzoyl-3-methyl-2-indolinone with a basic compound and replacing an aromatic amino group of the formed compound with a hydrogen atom. A very high yield of ketoprofen can be obtained through ordinary steps, which are short as a whole, without using chemicals of an extremely high toxicity such as cyanides or chemicals of a low handleability, such as liquid ammonia.

Procédé servant à préparer kétoprofène par benzoylation de 3-méthyle-2-indolinone avec un halogénure de benzoyle, par clivage de la liaison amido constituant la fraction de noyau à cinq éléments de 5-benzoyle-3-méthyle-2-indolinone obtenue avec un composé basique et par remplacement d'un groupe amino aromatique du composé obtenu par un atome d'hydrogène. On peut obtenir un rendement très important de kétoprofène par l'intermédiaire d'étapes ordinaires, courtes dans leur ensemble, sans utiliser de produits chimiques présentant une toxicité extrêmement élevée, tels que des cyanures, ou des produits chimiques peu maniables, tels que de l'ammoniac liquide.

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