Process for producing l-phenyl acetyl carbinol (pac), an...

Details Process for producing l-phenyl acetyl carbinol (pac), an... Process for producing l-phenyl acetyl carbinol (pac), an...

C - Chemistry, Metallurgy

12

P

195/86, 195/34.1

C12P 7/26 (2006.01) C12N 11/08 (2006.01)

Patent

CA 2000721

ABSTRACT A process for the production of L-phenyl acetyl carbinol (PAC) is carried out with an immobilized cell mass of non-viable cells of a mutant yeast strain that exhibits resistance to aldehyde inhibition during PAC production. Benzaldehyde and a source of pyruvate are reacted in an aqueous medium in the pres- ence of the immobilized cell mass. Cells in the cell mass con- tain endogenous pyruvate decarboxylase. Cell walls are chemi- cally crosslinked with polyazetidine and modified to increase permeability to the reactants. A cosolvent for benzaldehyde can be employed to increase PAC production. PAC is useful as an in- termediate in the preparation of 1-ephedrine and d-pseudoephedrine, two well-known medicinal chemicals.

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