Process for producing microparticles

A - Human Necessities – 61 – K

Patent

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A61K 9/50 (2006.01)

Patent

CA 2429103

A process for producing microparticles containing biologically active substance, in which process an aqueous solution of the said substance is prepared, this solution is mixed with an aqueous solution of PEG such that the substance is concentrated and/or solidified, the substance is optionally washed, the substance is mixed with an organic polymer solution, the composition obtained is mixed, after the admixture of said polymer solution, with an aqueous polymer solution, thereby forming an emulsion of droplets of first mentioned polymer as the internal phase, said droplets are solidified into microparticles, the microparticles are dried and a release-controlling shell is optionally applied to these.

L'invention concerne un procédé permettant de produire des microparticules contenant une substance biologiquement active. Dans ce procédé, une solution aqueuse de la substance est préparée, puis mélangée avec une solution aqueuse de polyéthylèneglycol, de manière à concentrer et/ou à solidifier la substance. Cette substance est éventuellement nettoyée, puis elle est mélangée avec une solution polymère organique. La composition obtenue est mélangée, après mélange de ladite solution polymère, avec une solution polymère aqueuse, ce qui permet de former une émulsion de gouttelettes du premier polymère susmentionné faisant office de phase interne. Les gouttelettes sont solidifier pour obtenir des microparticules, lesquelles sont séchées et une coquille permettant la libération prolongée peut être éventuellement appliquée.

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