C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
167/199, 260/219
C08B 37/08 (2006.01) C08B 37/00 (2006.01)
Patent
CA 1286286
A B S T R A C T A process for producing natural heparan sulphate and dermatan sulpha te for mixtures of proteoglycans from the aorta, myocardium and particularly vascularised organs, based on a series of precipita- tion and purification steps which enable the protein part of the proteoglycan to be eliminated and the two products to be obtained in substantially pure form, without any chemical or enzymatic degradation. When administered orally or parenterally, the heparan sulphate ob- tained exerts activation effects on antithrombin III and on the fibrinolytic process. The dermatan sulphate obtained exerts an inhibiting effect on Factor Xa and also possesses the property of activating the fibrinolytic effect of heparan sulphate.
503943
de Ambrosi Luigi
Del Bono Rinaldo
Ferrari Gianni
Pagella Piergiusseppe
de Ambrosi Luigi
Del Bono Rinaldo
Ferrari Gianni
Marks & Clerk
Mediolanum Farmaceutici S.p.a.
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