Process for producing norstatin derivatives

Details Process for producing norstatin derivatives Process for producing norstatin derivatives

C - Chemistry, Metallurgy

07

C

C07C 229/34 (2006.01) C07C 227/02 (2006.01) C07C 227/16 (2006.01) C07C 227/18 (2006.01) C07C 227/32 (2006.01) C07C 315/04 (2006.01) C07C 317/28 (2006.01)

Patent

CA 2309530

This invention to provide a process for producing an optically active threo-phenylnorstatin derivative which does not require a toxic cyanating agent or a costly reagent, or a complicated procedure, and can be practiced on a commercial scale. This invention is directed to a process for producing a .beta.-amino-.alpha.-hydroxy acid derivative which comprises treating either a .gamma.-amino- .beta.-keto sulfoxide derivative with a halogenating agent to produce a .gamma.-amino-.alpha.-halo-.beta.-keto sulfoxide derivative, treating the same with an acid and an alcohol to produce a .beta. -amino- .alpha. -keto ester derivative or .beta.-amino- .alpha.-keto acid derivative, and followed by reducing.

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