Process for producing nucleoside derivatives

Details Process for producing nucleoside derivatives Process for producing nucleoside derivatives

C - Chemistry, Metallurgy

12

P

C12P 19/38 (2006.01) C12N 9/18 (2006.01) C12P 19/40 (2006.01)

Patent

CA 2244314

There is disclosed a process for producing a nucleoside derivative of the formula [I]: (see fig. I) characterized by contacting 2',3',5'-O-triacylribonucleoside derivative of the formula [II]: (see fig. II) with an ester hydrolase: (i) capable of regio-selectively deacylating the acyl group at 5'-O-position in the formula [II] above, and (ii) having an amino acid sequence encoded by a gene which hybridizes to a nucleotide sequence encoding an amino acid sequence of SEQ ID NO: 1

Divulgation d'une méthode pour la production d'un dérivé de nucléoside de formule I (voir fig. I), par mise en contact d'un dérivé de 2',3',5'-O-triacylribonucléoside de formule II (voir fig. II) avec une ester-hydrolase, (i) apte à désacyler stéréosélectivement le groupe acyle en position 5'-O dans la formule II ci-dessus, (ii) possédant une séquence d'acides aminés codée par un gène qui donne par hybridation une séquence de nucléotides codant une séquence d'acides aminés SEQ ID NO: 1

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