Process for producing nucleosides

Details Process for producing nucleosides Process for producing nucleosides

C - Chemistry, Metallurgy

07

H

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C07H 19/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 1065315

ABSTRACT OF THE DISCLOSURE A nucleoside is produced by reacting a sugar derivative containing an -O-acyl or -O-alkyl group or a halogen atom in the 1-position with a silylated organic base in the presence of an ester selected from the group consisting of trialkylsilyl esters of mineral acids and trialkylsilyl esters of strong organic acids. For example, 2,4-bis-(trimethylsilyloxy)-pyrimidine is reacted with 1-O-acetyl-2,3,5-tri-0-benzoyl-.beta.-D-ribofuranose in the presence of trimethylsilyl perchlorate to produce uridine 2',3',5'- tri-O-benzoate.

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