Process for producing optically active atenolol and...

Details Process for producing optically active atenolol and... Process for producing optically active atenolol and...

C - Chemistry, Metallurgy

07

C

C07C 235/34 (2006.01) C07C 31/20 (2006.01) C07C 35/34 (2006.01) C07C 231/20 (2006.01)

Patent

CA 2157938

This is an improved process for producing an optically active atenolol useful as a .beta.-adrenergic blocker for the treatment of angina pectoris, arrhythmia and hypertension. The process comprises reacting an atenolol having lower optical purity with a Br~nsted's acid to form a salt thereof, separating selectively a salt of optically active atenolol having higher solubility from a salt of racemic atenolol having lower solubility in a solvent utilizing the difference of the solubility in the solvent, followed by removing the acid moiety from the thus-separated salt of optically active atenolol having high solubility.

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