C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 51/41 (2006.01) C07B 57/00 (2006.01) C07C 51/02 (2006.01) C07C 51/09 (2006.01) C07C 51/43 (2006.01) C07C 51/493 (2006.01) C07C 61/22 (2006.01)
Patent
CA 2746570
It has been demanded to provide a process for industrially producing an intermediate for a compound that exhibits an inhibitory effect on activated blood coagulation factor X and is useful as a preventive and/or therapeutic agent for thrombotic diseases. The present invention provides a process for producing the (R)-.alpha.-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid, comprising reacting 3-cyclohexene-1-carboxylic acid and (R)-.alpha.-phenylethylamine using a mixed solvent of water and acetone or a mixed solvent of water and ethyl acetate as a solvent.
La présente invention concerne un procédé de production industrielle d'un intermédiaire de composé présentant une action inhibitrice vis-à-vis du facteur de coagulation sanguine X activé et pouvant être employé en tant qu'agent prophylactique et/ou thérapeutique contre les maladies thrombotiques. La présente invention concerne un procédé de production de (S)-3-cyclohexène-1-carboxylate de (R)-a-phényléthylamine, le procédé étant caractérisé par la réaction de l'acide 3-cyclohexène-1-carboxylique avec la (R)-a-phényléthylamine en employant au titre de solvant un mélange d'eau et d'acétone ou un mélange d'eau et d'acétate d'éthyle.
Kubota Kazuo
Sato Koji
Daiichi Sankyo Company Limited
Marks & Clerk
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