Process for producing optically active chromene oxide compound

C - Chemistry – Metallurgy – 07 – D

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C07D 493/04 (2006.01) C07D 491/153 (2006.01)

Patent

CA 2645683

[PROBLEMS] To provide an efficient process for producing an optically active chromene oxide compound which is an important intermediate for a benzopyran compound effective in the treatment of arrhythmia. [MEANS FOR SOLVING PROBLEMS] The process for producing an optically active chromene oxide compound comprises using an optically active titanium complex represented by, e.g., the formula (1) or (2) as a catalyst to asymmetrically oxidize an optically active chromene compound with high enantioselectivity in high chemical yield.

Le problème à résoudre dans la cadre de la présente invention consiste à proposer un procédé efficace de production d'un composé oxyde de chromène optiquement actif qui est un intermédiaire important pour un composé benzopyranne efficace dans le traitement de l'arythmie. La solution proposée est un procédé de production d'un composé oxyde de chromène optiquement actif qui comprend l'utilisation d'un complexe de titane optiquement actif représenté, par exemple, par la formule (1) ou (2) en tant que catalyseur pour l'oxydation asymétrique d'un composé chromène optiquement actif avec une énantiosélectivité élevée et un rendement chimique élevé.

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