Process for producing paroxetine hydrochloride hydrate

Details Process for producing paroxetine hydrochloride hydrate Process for producing paroxetine hydrochloride hydrate

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4525 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2496727

A process for producing paroxetine hydrochloride hydrate, which comprises reacting (3S,4R)-1-tert-butoxycarbonyl-4-(4-fluorophenyl)-3-[(3,4- methylenedioxy)phenoxymethyl]piperidine with hydrogen chloride in the presence of water and then precipitating crystals in the presence of water.

L'invention concerne un procédé de production d'hydrate d'hydrochlorure de paroxétine consistant à faire réagir (3S, 4R)-1-tert-butoxycarbonyl-4-(4-fluorophényl)-3-[(3,4-méthylènedioxy)phénoxyméthyl]piperidine avec du chlorure d'hydrogène en présence d'eau et, ensuite, à précipiter des cristaux en présence d'eau.

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