Process for producing phenylene derivatives

Details Process for producing phenylene derivatives Process for producing phenylene derivatives

C - Chemistry, Metallurgy

07

C

260/312, 260/477

C07C 235/56 (2006.01) A61K 31/19 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 59/70 (2006.01) C07C 59/72 (2006.01) C07C 65/21 (2006.01) C07C 65/24 (2006.01) C07C 69/712 (2006.01) C07C 69/734 (2006.01) C07C 235/64 (2006.01) C07C 255/60 (2006.01) C07C 271/28 (2006.01) C07C 275/40 (2006.01) C07D 257/04 (2006.01) C07D 285/12 (2006.01) C07D 285/125 (2006.01) C07D 285/135 (2006.01)

Patent

CA 1273940

A B S T R A C T The present invention relates to novel phenylene derivatives of formula (I) or pharmaceutically acceptable salts thereof and a process for their preparation, (I) Image WHEREIN: A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R1 represents a hydrogen atom or a lower alkoxy group, X1 represents a group shown by -CH2CH2-, -CH=CH-, -CH2-Y1- (wherein Y1: -O-, -S- or -NH-), -Y1-CH2-, -CO-Y2 - (wherein Y2: -NH-, -CH2-Y1- or -Y1-CH2-) or -Y2-CO-, ? represents a group selected from: Image Image or WHEREIN: R2 is a hydrogen atom, a halogen atom, a nitro group, a hydroxy group, a lower alkoxy group, a carboxy group, a cyano group, an oxaloamido group (-NHCOCOOH)-, a lower alkoxycarbonyl group, a lower alkyl group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a carboxy- lower alkyl group, a lower alkoxycarbonyl lower alkyl group, a carboxy-lower alkylthio-lower alkyl group, a lower alkoxy- carbonyl-lower alkylthio-lower alkyl group, a halo-lower alkyl group, a carboxyl-lower alkoxy group, a lower alkoxy- carbonyl-lower alkoxy group, a lower alkanoyl-lower alkoxy group, a lower alkoxycarbonyl-lower alkoxycarbonyl-lower alkoxy group, a lower alkanoyl group or a group represented by formula: Image WHEREIN R4 and R5, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a carboxy- lower alkyl group, a lower alkoxycarbonyl-lower alkyl group, a lower alkanoyl group, a carboxy-lower alkanoyl group, a lower alkoxycarbonyl-lower alkanoyl group, a substituted or unsubstituted phenyl-lower alkoxycarbonyl-lower alkanoyl group, a carbamoyl group, a lower alkoxalyl group or a mono- or di-lower alkylaminocarbonyl group, R3 is a hydrogen atom, a hydroxy group or a lower alkoxy group, X2 represents a group represented by -CH=CH- or -Y3-Y4- WHEREIN Y3: a single bond, -O-, -S- or -NH-; Y4: an alkylene group having 1 to 6 carbon atoms which may be intervened by a sulfur atom, D represents a carboxy group, a lower alkoxycarbonyl group or a group represented by: Image provided that ? is: Image or Image or D is: Image when A is a hydrogen atom, the compounds of the present invention are useful as drugs particularily SRS-A (slow reacting substance of anaphylaxis) antagonists.

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