Process for producing plasminogen-containing composition

Details Process for producing plasminogen-containing composition Process for producing plasminogen-containing composition

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 38/48 (2006.01) A61L 2/00 (2006.01) C12N 9/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2128694

ABSTRACT This invention provides a process for producing a plasminogen-containing composition having improved safety as a pharmaceutical preparation, in which the loss of plasminogen activity is minimized and contaminated viruses are inactivated efficiently. The process for producing a plasminogen-containing composition in which viruses are inactivated comprises (1) contact-treating a plasminogen-containing composition having a possibility of viral contamination with trialkyl phosphate under a liquid condition and (2) removing the trialkyl phosphate. Preferably, the trialkyl phosphate contact treatment is carried out under a slightly acidic condition or the process further comprises the steps of (3) lyophilizing and (4) heat-treating the plasminogen-containing composition under a dry condition. - 18 -

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