Process for producing protein a and composition thereof

Details Process for producing protein a and composition thereof Process for producing protein a and composition thereof

C - Chemistry, Metallurgy

12

N

195/129, 195/1.2

C12N 15/31 (2006.01) C07K 14/31 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1307483

ABSTRACT OF THE DISCLOSURE The gene coding for a protein A-like material has been successfully cloned and expressed for the first time. The cloning of this gene with its nucleotide sequence characterization, also disclosed, enables those skilled in the art to obtain quantities of a protein A-like material nucleotide sequence for cloning in various host-vector systems. Protein A is well known as a valuable component of a variety of diagnostic test systems. The protein A-like material of the subject invention, and subfragments thereof, have the protein A properties of binding to IgG at the Fc region and activation of polyclonal antibody synthesis. Thus, these entities are useful in the same manner as protein A.

439706

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