Process for producing (r)-2-hydroxy-1-phenoxypropane derivative

Details Process for producing (r)-2-hydroxy-1-phenoxypropane derivative Process for producing (r)-2-hydroxy-1-phenoxypropane derivative

C - Chemistry, Metallurgy

12

P

C12P 7/22 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2321450

To efficiently produce an (R)-2-hydroxy-1-phenoxypropane derivative which is useful as a drug intermediate at a high optical purity, a phenoxyacetone derivative is R-selectively reduced by using a carbonyl reductase originating in candida, or an optionally processed culture medium of a microorganism capable of producing the above enzyme.

Afin de produire efficacement un dérivé (R)-2-hydroxy-1-phénoxypropane utile en tant qu'intermédiaire médicamenteux à pureté optique élevée, on réduit de manière R-sélective un dérivé phénoxyacétone en utilisant une réductase carbonylée provenant de candida, ou un milieu de culture éventuellement traité d'un micro-organisme pouvant produit ladite enzyme.

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