Process for producing ribonucleosides

Details Process for producing ribonucleosides Process for producing ribonucleosides

C - Chemistry, Metallurgy

12

N

195/120, 195/35.

C12N 11/04 (2006.01) C12P 19/38 (2006.01)

Patent

CA 1279279

ABSTRACT OF THE DISCLOSURE The present invention provides a process for producing ribonucleosides by reacting a base donor with a ribose compound in the presence of nucleoside phosphorylase to form N-glycosidic linkage between the base moiety of the base donor and the ribose moiety of the ribose compound, which process is characterized by the use of an immobilized nucleoside phosphorylase preparation obtained by subjecting a mixture of an enzyme source having nucleosidase activity in addition to nucleoside phosphorylase activity and a photo-curable resin having a photosensitive radical at any position of the prepolymer chain structure thereof to irradiation with actinic rays, whereby the activity of the nucleosidase concomitantly present in the enzyme source is inhibited.

527814

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