Process for producing simvastatin and analogs thereof

Details Process for producing simvastatin and analogs thereof Process for producing simvastatin and analogs thereof

C - Chemistry, Metallurgy

07

F

C07F 5/04 (2006.01) C07D 309/30 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2173830

A process is disclosed for the preparation of simvastatin and its analogs through a novel intermediate (III), which enables a selective .alpha. carbon alkylation of the C-8 acyl side chain.

L'invention concerne un procédé pour la préparation de la simvastatine et de ses analogues à l'aide d'un nouvel intermédiaire (III), ce qui permet une alkylation sélective de carbone en position .alpha. de la chaîne latérale acyle C-8.

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