Process for producing small particles of biologically active...

A - Human Necessities – 61 – K

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A61K 9/16 (2006.01) B01J 10/00 (2006.01)

Patent

CA 2030551

Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0.1 to 10 micrometers with greater than 70 to 95% of the initial biological activity of the molecules in solution.

On produit de petites particules de molécules biologiquement actives en pulvérisant des solutions des molécules au moyen d'une buse dans des gaz liquéfiés très froids qui font geler immédiatement les gouttelettes pulvérisées. Les particules gelées résultantes ayant un diamètre d'environ 10 à 90 micromètres sont lyophilisées en vue de produire des particules poreuses, mises en suspension dans un non-solvant pour les molécules, et exposées à une énergie ultrasonique ou à l'homogénéisation en vue de produire des particules ayant un diamètre de 0,1 à 10 micromètres avec plus de 70 à 95 % de l'activité biologique initiale des molécules en solution.

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