Process for producing spherical fine particles containing drug

Details Process for producing spherical fine particles containing drug Process for producing spherical fine particles containing drug

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61J 3/06 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) B01J 2/10 (2006.01) B01J 2/14 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2347775

A process for efficiently producing spherical fine particles containing a drug for use in the form of an easy-to-take, sustained-release preparation, characterized by adding a solution of a binder to a mixture comprising an excipient powder which has the property of holding a solvent (and preferably has an average major diameter of 40 µm or smaller) and a drug powder (preferably having an average major diameter of 50 µm or smaller) and granulating the resultant mixture by high-speed rolling to form the spherical fine particles (having an average particle diameter of 60 to 200 µm).

L'invention se rapporte à un procédé de production de fines particules sphériques contenant un médicament, destinées à être utilisées sous forme d'une préparation à libération prolongée et facile à administrer. Ce procédé consiste premièrement à ajouter une solution d'un liant à un mélange comportant une poudre à effet d'excipient qui possède la propriété de retenir un solvant (et dont les particules possèdent de préférence un diamètre extérieur moyen inférieur ou égal à 40 µm) et une poudre médicamenteuse (dont les particules possèdent de préférence un diamètre extérieur moyen inférieur ou égal à 50 µm), et deuxièmement à granuler le mélange résultant par broyage à grande vitesse de manière à former les fines particules sphériques (dotées d'un diamètre moyen compris entre 60 et 200 µm).

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