Process for producing stable sulpho-adenosyl-l- methionine...

Details Process for producing stable sulpho-adenosyl-l- methionine... Process for producing stable sulpho-adenosyl-l- methionine...

C - Chemistry, Metallurgy

12

P

195/139, 195/78,

C12P 19/40 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01)

Patent

CA 1223535

ABSTRACT A process is described for the large-scale industrial production of any stable SAMe salt at very high purity and with a yield of about 90% or more. The new process is characterised by the following basic operations: a) production of yeast containing 12-20 g/kg of SAMe, b) cell lysis and recovery of the SAMe-rich lysate, c) ultrafiltration of the lysate, d) passage through weak acid ion exchange resin, e) passage through absorption resin, f) concentration by reverse osmosis, g) spray-drying the concentrated aqueous solution of SAMe salt.

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