Process for producing substances produced by cells

Details Process for producing substances produced by cells Process for producing substances produced by cells

C - Chemistry, Metallurgy

12

N

167/154, 195/134

C12N 11/10 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) C07K 14/52 (2006.01) C07K 14/56 (2006.01) C07K 14/565 (2006.01) C07K 14/62 (2006.01) C12N 5/00 (2006.01) C12N 11/04 (2006.01) A61K 35/12 (2006.01)

Patent

CA 1172961

Abstract of the Disclosure Disclosed is a system and process for producing substances produced in cells such as antibodies and biological response modifiers. Cells which produce the substance of interest are encapsulated within semipermeable membranes having an upper limit of permeability sufficient to allow traverse of ions, amino acids and other cell nutrients and then suspended in a culture medium. Serum components or other high molecular weight materials needed for ongoing viability and normal in vitro metabolism of certain types of cells may be included within the intracapsular volume and may be excluded from the extracapsular medium by limiting the permeability of the membranes. The substance of interest collects either in the intracapsular volume or the extracapsular medium, depending on the degree of permeability of the membranes and on the molecular weight of the substance.

398218

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