Process for producing thiophene derivative

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01)

Patent

CA 2125820

A process for producing a thiophene derivative expressed by the general formula (2): (see formula 2) wherein R1 and R2 represent independently hydrogen, an alkyl group, a phenyl group which may be substituted, an aryl group, an alkenylmethyl group, or a benzyl group which may be substituted, Y represents an oxygen atom or a sulfur atom, and Z represents an alkyl group having a carboxyl group or an alkoxy group at terminal, which is made up the step of catalytically reducing a compound having the general formula (1): (see formula 1) wherein R1, R2, Y, and Z are as defined above, with hydrogen in a solvent mixture of at least one of alcohols and water in the presence of a palladium catalyst soluble in organic solvents.

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