Process for production of azulene derivatives and...

Details Process for production of azulene derivatives and... Process for production of azulene derivatives and...

C - Chemistry, Metallurgy

07

D

C07D 309/10 (2006.01) C07C 43/225 (2006.01) C07C 49/223 (2006.01) C07H 7/04 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2572149

A process for producing azulene derivatives useful as Na+-glucose cotransporter inhibitor easily and simply in high yield at a low cost which is industrially advantageous and excellent in environmental protection, characterized by subjecting at least one compound selected from among specific penta- and tetraacyl precursors of the azulene derivatives and salts of the precursors to reduction and deblocking to obtain a C-glycoside compound; and useful intermediates obtained in the above process.

Procédé pour fabriquer des dérivés d~azulène utiles en tant qu~inhibiteurs des co-transporteurs Na+/glucose facilement et simplement avec un rendement élevé à faible coût qui est industriellement avantageux et excellent en terme de protection environnementale, caractérisé par la soumission d~au moins un composé sélectionné parmi les précurseurs spécifiques de penta- et de tétra-acyle des dérivés d~azulène et les sels des précurseurs à une réduction et par le déblocage afin d~obtenir un composé de C-glycoside ; et intermédiaires utiles obtenus dans le procédé précédent.

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