Process for production of beta-chloroalanine

C - Chemistry – Metallurgy – 07 – C

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260/525.1

C07C 227/02 (2006.01) A61K 31/195 (2006.01) C07C 229/20 (2006.01) C07C 255/24 (2006.01)

Patent

CA 1111444

- 20 - PROCESS FOR PRODUCTION OF BETA-CHLOROALANINE ABSTRACT OF DISCLOSURE A novel production process of .beta.-chloroalanine from chloroacetaldehyde is provided. In this process, a bisulfite or sulfite addition compound of chloroacetaldehyde is first reacted, in an aqueous solution, with ammonia and, then, reacted with hydrocyanic acid or a salt thereof. Thus, .alpha.-amino-.beta.-chloropropionitrile is formed. This .alpha.-amino- -.beta.-chloropropionitrile is hydrolyzed under an acidic condi- tion to form .beta.-chloroalanine.

352668

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