C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 477/00 (2006.01)
Patent
CA 2596951
Disclosed is an intermediate for the synthesis of a carbapenem which is advantageous for the industrial production of the carbapenem. A process for producing a compound (I) or a pharmaceutically acceptable salt or solvate thereof or a crystal thereof, comprising reacting a compound (III) with a compound (IV) in the presence of a secondary amine; a crystal of a benzyl alcohol-solvated form of the compound (I) or the like; a method for deprotecting the compound (I) by using a Pd catalyst; and a crystal of the compound (IV) or the like.
La présente invention concerne un intermédiaire destiné à la synthèse d'un carbapénème qui est avantageux pour la production industrielle du carbapénème. L'invention décrit un procédé de production d'un composé(I) ou d'un sel ou solvate pharmaceutiquement acceptable de celui-ci ou d'un cristal de celui-ci, qui consiste à faire réagir un composé (III) avec un composé (IV) en présence d'une amine secondaire; un cristal d'une forme alcool benzylique-solvatée du composé (I) ou élément similaire; un procédé de déprotection du composé (I) utilisant un catalyseur de Pd; et un cristal du composé (IV) ou élément similaire.
Hozumi Yasuyuki
Komurasaki Tadafumi
Noguchi Kouichi
Uenaka Masaaki
Mccarthy Tetrault Llp
Shionogi & Co. Ltd.
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