Process for production of compound labeled with radioactive...

C - Chemistry – Metallurgy – 07 – H

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C07H 5/02 (2006.01) A61K 51/00 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2632553

[PROBLEMS] To provide a process for production of 18F-FDG, which can produce of 18F-FDG with a high and steady yield. [MEANS FOR SOLVING PROBLEMS] A process for production of a compound labeled with radioactive fluorine, comprising the steps of: preparing a reaction solution by adding TATM and an inert organic solvent to a mixture of a [18F]fluoride ion, a phase transfer catalyst and a potassium ion under hermetic conditions; subjecting the reaction solution to a reaction under hermetic, specified reaction conditions to yield 18F-TAFDG; and subjecting the 18F-TAFDG to deprotection and optionally purification to yield 18F-FDG.

Le problème à résoudre dans le cadre de la présente invention consiste à proposer un procédé de production de 18F-FDG, pouvant produire 18F-FDG avec un rendement élevé et constant. La solution proposée est un procédé de production d'un composé marqué avec du fluor radioactif, comprenant les étapes consistant à : préparer une solution de réaction en ajoutant TATM et un solvant organique inerte à un mélange d~un ion fluorure [18F], d~un catalyseur de transfert de phases et d~un ion potassium dans des conditions hermétiques ; soumettre la solution de réaction à une réaction dans des conditions de réaction hermétiques et spécifiques pour donner 18F-TAFDG ; et soumettre le 18F-TAFDG à une déprotection et éventuellement à une purification pour donner 18F-FDG.

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