Process for production of ethylenediamine derivatives having...

C - Chemistry – Metallurgy – 07 – C

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C07C 271/22 (2006.01) C07C 269/06 (2006.01) C07C 271/20 (2006.01) C07D 207/09 (2006.01) C07D 231/14 (2006.01) C07D 307/85 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2647590

Ethylenedamine derivatives having a halogenated carbamate group and an acyl group can be produced by performing the catalytic hydrogenation of an aminonitrile having a halogen-substituted carbamate group in the presence of an acid and then performing the acylation of the resulting product. The aminonitrile (i.e., a starting material) can be prepared in a high yield by performing the halogenated carbamatation of an amino acid amide in the presence of water and then reacting the resulting product with a deoxidizing agent such as a vilsmeier reagent.

Selon l'invention un dérivé d'éthylènediamine ayant un groupement carbamate halogéné et un groupement acyle peut être produit en effectuant l'hydrogénation catalytique d'un aminonitrile ayant un groupement carbamate substitué par halogène en présence d'un acide, puis en effectuant l'acylation du produit résultant. L'aminonitrile (c'est-à-dire un produit de départ) peut être préparé avec un rendement élevé en effectuant la carbamatation halogénée d'un amide d'acide aminé en présence d'eau, puis en faisant réagir le produit résultant avec un agent désoxydant tel que le réactif de Vilsmeier.

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