Process for production of imidazole derivatives

Details Process for production of imidazole derivatives Process for production of imidazole derivatives

C - Chemistry, Metallurgy

07

D

260/315.25

C07D 233/56 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1136634

ABSTRACT OF THE DISCLOSURE Imidazole derivatives of the general formula (I): Image (I) wherein Y is a carboxyl group, an alkoxycarbonyl group, a cyano group, a hydroxymethyl group, an aminomethyl group, a formyl group or a carbamoyl group, and A and B, which may be the same or different, is each a straight- or branched-chain alkylene or alkenylene group, and n and m, which may be the same or different, is each zero or 1, with the proviso that when A is a methylene group or n is zero, m is 1; and pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for the treatment of inflammation, hypertension, thrombus, cerebral apoplexy and asthma.

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